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Frozen Embryo & Eggs Transfer

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Frozen Embryos

Frozen embryos are created through IVF technology. Sperm and eggs are combined outside the body to form fertilized embryos, which are then cultured until the third day to form early embryos or the fifth day to form blastocysts. These embryos (blastocysts) are then stored in liquid nitrogen at -196°C.

Suitable Candidates For Frozen Embryos

Remaining Quality Embryos:

After embryo transfer in an IVF cycle, the remaining quality embryos can be frozen for future use.

Suboptimal Uterine Environment:

In cases where the uterine environment is not suitable for pregnancy during the IVF cycle (e.g., ovarian hyperstimulation, poor endometrial condition, uterine fibroids), embryos can be frozen and transferred at a later, more suitable time.

PGS/PGD Genetic Screening:

Due to the time required for genetic testing and diagnosis, embryos need to be frozen until results are available.

Potential Loss of Ovarian Function:

Patients who may lose ovarian function (e.g., due to chemotherapy, radiation therapy, or surgery) can choose to freeze embryos to preserve fertility.

    Frozen Eggs

    Also known as cryopreserved eggs, this involves directly freezing healthy, fresh eggs to prevent quality decline due to aging of the eggs and ovaries. When the woman decides to conceive, the eggs are thawed and fertilized with sperm.

    Suitable Candidates For Frozen Eggs

    Older Women: Women over 30 who do not yet have marriage or childbearing plans.

    Ovarian Function Loss: Women who need chemotherapy, radiation therapy, or surgery that may harm ovarian function.

    Premature Ovarian Failure: Women experiencing early ovarian failure due to infection, tumors, or autoimmune factors.

    Women with Diseases: Women with conditions like pelvic inflammatory disease that damage the fallopian tubes and reduce egg viability.

    IVF Cycle: Women who cannot proceed with immediate IVF after egg retrieval due to other reasons, requiring egg freezing to maintain egg viability.

      Freezing Technology

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      RFG Freezing Technology

      RFG uses advanced vitrification freezing technology, which involves solidifying high-concentration cryoprotectants at ultra-low temperatures to form an amorphous, glass-like solid. This preserves the normal distribution of molecules and ions in the liquid state, protecting cells during vitrification. Dehydration of cells in cryoprotectant solution to a certain extent causes endogenous cytoplasmic macromolecules like proteins and concentrated cryoprotectants to protect the cells during rapid cooling.

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      Advantages of Frozen Embryos

      Preserve Remaining Embryos: Can save surplus embryos after IVF transfer.

      Reduce Multiple Pregnancy Risk: Lower the occurrence of multiple pregnancies.

      Decrease OHSS: Reduce the risk of ovarian hyperstimulation syndrome (OHSS).

      Preserve Fertility: Help preserve female fertility.

      Await Genetic Diagnosis: Wait for preimplantation genetic diagnosis and screening (PGD/PGS) results.

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      Frozen Embryos ≠ Frozen Eggs

      • Frozen Embryos: The structure and morphology of embryos are more stable, making them less affected by freezing and thawing processes, and they have a high survival rate.
      • Frozen Eggs: Require higher technical standards, including lab technology, equipment, and reproductive specialist expertise. Eggs are large cells with abundant cytoplasm and high water content, making them sensitive to temperature changes and prone to ice crystal formation, which can damage cell structure, chromosomes, and genetic material, leading to lower survival rates after thawing.